Skip to main content

Table 2 Column and Simulation Parameters for Examples 1 and 2

From: Standing-wave Design of Three-Zone, open-loop non-isocratic SMB for purification

System Parameters
LC (cm) Number of columns Column Diameter (cm) dp (μm) ε b ε p Y \( {E}_{b,i}^j \) Film Mass Transfer Coefficient
2.5 3 Exp. 1: 0.5 Exp. 1: 44 0.35 0.69 0.99 Chung and Wen Wilson and Geankoplis
Exp. 2: 0.7 Exp. 2: 34
Isotherm Parameters
Example 1
Target Compound Impurity
q max K A pH ref n a 1
73 g/L 6.1 L/g 7.4 16.6 1.6
Example 2
a o, i x i a o, i x i
0.79 2.01 0.79 2.01
Simulation Settings and Numerical Parameters
PDE Discretization Method Number of Elements Material Balance Assumption Kinetic Model Assumption Lumped Resistance Film Mode
QDS Exp. 1: 181 Convection with Estimated Dispersion Linear Lumped Resistance Exp. 1: Fluid
Exp. 2: 150 Exp. 2: Solid
Mass Transfer/Film Coefficient Loading Basis Step Size Integration Method
Constant Volume Basis 0.000005–0.005 Fixed Step Implicit Euler