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Table 3 Overview of the uncertainty parameters

From: Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing

Category

Type of variable

Number of parameters used in the case study

Internal variables determined at later stages

 Dosage unit size and composition

Continuous

9

 Number of PATs installed

Continuous

2

 Manufacturing space

Continuous

2

 Manufacturing rate in continuous technology

Continuous

1

 Time related to production, cleaning, and test

Continuous

19

 Losses

Continuous

11

 Number of operators

Discrete

21

 Number of lots in one campaign manufacturing

Discrete

2

External variables given at later stages

 Raw material price

Continuous

7

 Demand/required amount

Discrete

6

 Man-hours of work in the maintenance of PAT per one PAT

Continuous

1

 Disposal/HVAC cost

Continuous

2

 Drug price

Continuous

1

 Success/failure of clinical development

Categorical

1