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Table 5 Standard values of tablet weight and composition ratio applied to scenarios

From: Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing

 

Main dose

Low dose (proportional)

Low dose (common)

Tablet weight [kg tablet−1]

3.0 × 10−4

6.0 × 10−5

3.0 × 10−4

Composition ratio [−]

 API

0.30

0.30

0.060

 Excipient

0.56

0.56

0.80

 Disintegrant

0.10

0.10

0.10

 Binder

0.015

0.015

0.015

 Lubricant

0.0050

0.0050

0.0050

 Coating agent

0.020

0.020

0.020

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BMC Chemical Engineering

ISSN: 2524-4175

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