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Table 6 Overview of the generated alternatives

From: Superstructure-based process synthesis and economic assessment under uncertainty for solid drug product manufacturing

Alternative number

Combination of the general units in Fig. 1

Technology

Formulation strategy

1

\( {\mathrm{U}}_{10}^{\mathrm{C}} \), \( {\mathrm{U}}_{12}^{\mathrm{C}} \), U13, \( {\mathrm{U}}_{14}^{\mathrm{C}} \), U15, \( {\mathrm{U}}_{16}^{\mathrm{C}} \), U18

Continuous

Proportional

2

\( {\mathrm{U}}_{10}^{\mathrm{C}} \), \( {\mathrm{U}}_{12}^{\mathrm{C}} \), U13, \( {\mathrm{U}}_{14}^{\mathrm{C}} \), U15, \( {\mathrm{U}}_{16}^{\mathrm{C}} \), U18

Continuous

Common

3

\( {\mathrm{U}}_{10}^{\mathrm{B}} \), \( {\mathrm{U}}_{12}^{\mathrm{B}} \), U13, \( {\mathrm{U}}_{14}^{\mathrm{B}} \), U15, \( {\mathrm{U}}_{16}^{\mathrm{B}} \), U18

Batch (high-shear)

Proportional

4

\( {\mathrm{U}}_{10}^{\mathrm{B}} \), \( {\mathrm{U}}_{12}^{\mathrm{B}} \), U13, \( {\mathrm{U}}_{14}^{\mathrm{B}} \), U15, \( {\mathrm{U}}_{16}^{\mathrm{B}} \), U18

Batch (high-shear)

Common

5

\( {\mathrm{U}}_{11}^{\mathrm{B}} \), U13, \( {\mathrm{U}}_{14}^{\mathrm{B}} \), U15, \( {\mathrm{U}}_{16}^{\mathrm{B}} \), U18

Batch (fluidized-bed)

Proportional

6

\( {\mathrm{U}}_{11}^{\mathrm{B}} \), U13, \( {\mathrm{U}}_{14}^{\mathrm{B}} \), U15, \( {\mathrm{U}}_{16}^{\mathrm{B}} \), U18

Batch (fluidized-bed)

Common